https://wikianesthesia.org/w/api.php?action=feedcontributions&feedformat=atom&user=Cmclendon 2026-05-02T13:26:56Z User contributions MediaWiki 1.37.1 https://wikianesthesia.org/w/index.php?title=Dexmedetomidine&diff=13650 2022-08-09T15:41:53Z

<p>Cmclendon: Added some details</p> <hr /> <div>{{Infobox drug reference<br /> | trade_names = <br /> | image_file = Dexmedetomidine.svg<br /> | drug_class = Sedative hypnotic<br /> | drug_class_color = sedative_hypnotic<br /> | uses = <br /> | contraindications = <br /> | routes = IV, IM, IN<br /> | dosage = <br /> | dosage_calculation = dexmedetomidine<br /> | mechanism = Alpha-2 agonism<br /> | adverse_effects = <br /> | time_onset = <br /> | duration = <br /> | metabolism = <br /> | halflife_redistribution = <br /> | halflife_elimination = <br /> | clearance = <br /> | protein_binding = <br /> }}<br /> <br /> Dexmedetomidine is an alpha-2 agonist that has been shown to have analgesic, anxiolytic, and sedative properties&lt;ref name=&quot;:0&quot;&gt;{{Cite journal|last=DiLorenzo|first=Amy N.|last2=Schell|first2=Randall M.|date=2014-08|title=Morgan &amp;amp; Mikhail’s Clinical Anesthesiology, 5th Edition|url=http://dx.doi.org/10.1213/ane.0000000000000298|journal=Anesthesia &amp;amp; Analgesia|volume=119|issue=2|pages=495–496|doi=10.1213/ane.0000000000000298|issn=0003-2999}}&lt;/ref&gt;. <br /> <br /> == Uses&lt;!-- Describe uses of the drug. If appropriate, add subsections for each indication. --&gt; ==<br /> ICU, intra-operative, and procedural sedation without respiratory depression or amnestic properties. May decrease opioid requirement, more so due to sedating rather than analgesic effects.<br /> <br /> ==Contraindications&lt;!-- List contraindications and precautions for use of the drug. --&gt;==<br /> <br /> ===Absolute contraindications&lt;!-- List absolute contraindications for use of the drug. If none, this section may be removed. --&gt;===<br /> <br /> ===Precautions===<br /> Should be used with caution with any drugs that lower heart rate or cause hypotension as it may contribute to these hemodynamic changes.&lt;ref name=&quot;:0&quot; /&gt; &lt;!-- List precautions for use of the drug. If none, this section may be removed. --&gt;<br /> <br /> ==Pharmacology==<br /> <br /> ===Pharmacodynamics&lt;!-- Describe the effects of the drug on the body. If appropriate, add subsections by organ system --&gt;===<br /> <br /> ====Mechanism of action&lt;!-- Describe the mechanism of action for the primary uses of the drug. --&gt;====<br /> Central α-2 agonist with a 1600:1 affinity for α-2 receptors over α-1 receptors. <br /> <br /> ====Adverse effects&lt;!-- Describe any potential adverse effects of the drug. --&gt;====<br /> Risk of hypotension and bradycardia, in a dose-dependent manner. Night terrors and transient behavioral effects in children have been reported when used for pre-anesthetic sedation, due to calming effects without amnestic properties.<br /> <br /> ===Pharmacokinetics&lt;!-- Describe the pharmacokinetics of the drug. --&gt;===<br /> <br /> ==Chemistry and formulation&lt;!-- Describe the chemistry and formulation of the drug. --&gt;==<br /> <br /> ==History&lt;!-- Describe the historical development of the drug. --&gt;==<br /> <br /> ==References==<br /> <br /> [[Category:Drug reference]]<br /> [[Category:Sedative hypnotics]]</div>

Cmclendon