https://wikianesthesia.org/w/api.php?action=feedcontributions&feedformat=atom&user=KellenWikiAnesthesia - User contributions [en]2026-05-05T06:01:33ZUser contributionsMediaWiki 1.37.1https://wikianesthesia.org/w/index.php?title=Meperidine&diff=14245Meperidine2022-10-22T20:44:01Z<p>Kellen: This page was blank. Added some basic information, receptors, precautions, etc.</p>
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<div>{{Infobox drug reference<br />
| trade_names = Demerol<br />
| image_file = Meperidine.svg<br />
| drug_class = Opioid<br />
| drug_class_color = opioid<br />
| uses = Analgesia<br />
Shivering<br />
| contraindications = <br />
| routes = <br />
| dosage = <br />
| dosage_calculation = meperidine<br />
| mechanism = μ-opioid agonism<br />
| adverse_effects = <br />
| time_onset = <br />
| duration = <br />
| metabolism = <br />
| halflife_redistribution = <br />
| halflife_elimination = <br />
| clearance = <br />
| protein_binding = <br />
}}<br />
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Provide a brief summary of this drug here.<br />
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== Uses<!-- Moderate to severe pain requiring an opioid analgesic. It is 1/10th the potency relative to Morphine. -->==<br />
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== Contraindications<!-- List contraindications and precautions for use of the drug. --> ==<br />
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=== Absolute contraindications<!-- Due to its active metabolite, Normeperidine, which is half as potent as the parent compound with an elimination half time of 15 hours it can accumulate in those with impaired renal clearance. Normeperidine can cause a reduction in the seizure threshold and cause myoclonus. Thus avoid it if the patient is on dialysis and use cautiously in the elderly patient. Also be aware if the patient is on any CYP3A4 inhibitors this could lead to an increase in plasma concentrations of the drug. If the patient is on or has taken any MAO-Inhibitors in the last 2 weeks, this could lead to excessive serotonin levels causing symptoms such as hyperthermia, hyperreflexia, mydriasis, akathesia, change in level of consciousness (agitation), tremors, seizures, and death. This is known as Serotonin Syndrome. The use of Methylene Blue, phenylpiperidine opioids (fentanyl, methadone, etc.) and SSRI's all can increase the risk of Serotonin Syndrome. -->===<br />
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=== Precautions<!-- Histamine releasing agent. -->===<br />
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== Pharmacology ==<br />
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=== Pharmacodynamics<!-- Describe the effects of the drug on the body. If appropriate, add subsections by organ system --> ===<br />
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==== Mechanism of action<!-- Meperidine (Demerol) is a Phenylpiperidine that provides analgesia via strong Mu receptor agonism. Its antishivering effects likely result from Kappa receptor agonism. In addition, it is structurally similar to atropine and thus exhibits anticholinergic properties leading to tachycardia, mydriasis, and xerostomia. Meperidine also is a weak serotonin reuptake inhibitor thus concurrent administration with MAO-I's can lead to Serotonin Syndrome. It also works on sodium channels thus exhibiting a local anesthetic effect. Additionally, it causes histamine release. -->[https://www.ncbi.nlm.nih.gov/books/NBK470362/] <ref name=":0">{{Cite book|url=https://www.worldcat.org/oclc/989077162|title=Clinical anesthesia|date=2017|others=Paul G. Barash, Bruce F. Cullen, Robert K. Stoelting, Michael K. Cahalan, M. Christine Stock, Rafael A. Ortega|isbn=978-1-4963-3701-6|edition=Eighth edition|location=Philadelphia, PA|oclc=989077162}}</ref> ====<br />
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==== Adverse effects<!-- Describe any potential adverse effects of the drug. --> ====<br />
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=== Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. --> ===<br />
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== Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. --> ==<br />
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== History<!-- First synthetic opioid developed in 1939 --><ref name=":0" /> ==<br />
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== References ==<br />
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[[Category:Drug reference]]<br />
[[Category:Opioids]]<br />
[[Category:Opioid analgesics]]</div>Kellen