Fentanyl - Revision history

Jashvin at 02:31, 2 February 2023

2023-02-02T02:31:26Z

← Older revision		Revision as of 19:31, 1 February 2023
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	}}		}}

	'''Fentanyl''' is an opioid used for analgesia.		'''Fentanyl''' is a synthetic, lipophilic phenylpiperidine opioid agonist used for analgesia. It is highly lipophilic leading to fast passage across the blood-brain barrier with a 6.8 minute onset time. Fentanyl will also rapidly redistribute to adipose and fatty tissue leading to a short duration of action.

	==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==		==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==

			* Administration
			** IV, IM, transdermal, intranasal, intrathecal, epidural, buccal.

	==Contraindications<!-- List contraindications and precautions for use of the drug. -->==		==Contraindications<!-- List contraindications and precautions for use of the drug. -->==
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	===Precautions<!-- List precautions for use of the drug. If none, this section may be removed. -->===		===Precautions<!-- List precautions for use of the drug. If none, this section may be removed. -->===

			*

	==Pharmacology==		==Pharmacology==
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	====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->====		====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->====

			* µ-selective opioid receptor
			* Low affinity: delta & kappa opioid receptors

	====Adverse effects<!-- Describe any potential adverse effects of the drug. -->====		====Adverse effects<!-- Describe any potential adverse effects of the drug. -->====

	===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->===		===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->===

			* Context Sensitive Half Time
			** Infusion or repeated doses lead to prolong duration of action as drug redistributes back from tissue to plasma.

	==Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. -->==		==Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. -->==
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	==References==		==References==

			# Comer SD, Cahill CM. Fentanyl: Receptor pharmacology, abuse potential, and implications for treatment. Neurosci Biobehav Rev. 2019 Nov;106:49-57.

	[[Category:Drug reference]]		[[Category:Drug reference]]

Chris.Rishel: Added embedded dosage calculation

2022-03-30T07:15:54Z

Added embedded dosage calculation

← Older revision		Revision as of 00:15, 30 March 2022
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	{{Infobox drug reference		{{Infobox drug reference
	\| trade_names =Actiq, Duragesic, Sublimaze		\| trade_names = Actiq, Duragesic, Sublimaze
	\| drug_class =Opioid		\| drug_class = Opioid
	\| drug_class_color =opioid		\| drug_class_color = opioid
	\| uses =Analgesia		\| uses = Analgesia
	\| contraindications =		\| contraindications =
	\| routes =Buccal, Epidural, Intrathecal, Intravenous, Transdermal		\| routes = Buccal, Epidural, Intrathecal, Intravenous, Transdermal
	\| dosage =		\| dosage =
	\|halflife_elimination=16 hours\|formula=5 minutes\|image_file=Fentanyl.svg\|protein_binding=80-85%\|clearance=\|time_onset=5 minutes\|halflife_redistribution=6 minutes (initial)		\| halflife_elimination = 16 hours
	1 hour (slow)\|metabolism=Hepatic (CYP3A4)\|duration=30-60 minutes\|adverse_effects=\|mechanism=μ-opioid agonism\|molar_mass=336.479 g/mol}}		\| formula = 5 minutes
			\| image_file = Fentanyl.svg
			\| protein_binding = 80-85%
			\| clearance =
			\| time_onset = 5 minutes
			\| halflife_redistribution = 6 minutes (initial)
			1 hour (slow)
			\| metabolism = Hepatic (CYP3A4)
			\| duration = 30-60 minutes
			\| adverse_effects =
			\| dosage_calculation = fentanyl
			\| mechanism = μ-opioid agonism
			\| molar_mass = 336.479 g/mol
			}}

	'''Fentanyl''' is an opioid used for analgesia.		'''Fentanyl''' is an opioid used for analgesia.

Chris.Rishel at 11:38, 12 November 2021

2021-11-12T11:38:37Z

← Older revision		Revision as of 04:38, 12 November 2021
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	[[Category:Drug reference]]		[[Category:Drug reference]]
	[[Category:Opioids]]		[[Category:Opioids]]
	[[Category:Opioid ~~agonists~~]]		[[Category:Opioid analgesics]]
	[[Category:Synthetic opioids]]		[[Category:Synthetic opioids]]
	[[Category:Analgesics]]		[[Category:Analgesics]]
	[[Category:Local anesthetic adjuvants]]		[[Category:Local anesthetic adjuvants]]

Chris.Rishel at 09:09, 12 November 2021

2021-11-12T09:09:28Z

← Older revision		Revision as of 02:09, 12 November 2021
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	\| dosage =		\| dosage =
	\|halflife_elimination=16 hours\|formula=5 minutes\|image_file=Fentanyl.svg\|protein_binding=80-85%\|clearance=\|time_onset=5 minutes\|halflife_redistribution=6 minutes (initial)		\|halflife_elimination=16 hours\|formula=5 minutes\|image_file=Fentanyl.svg\|protein_binding=80-85%\|clearance=\|time_onset=5 minutes\|halflife_redistribution=6 minutes (initial)
	1 hour (slow)\|metabolism=Hepatic (CYP3A4)\|duration=30-60 minutes\|adverse_effects=\|mechanism=~~Opioid~~-~~receptor~~ agonism\|molar_mass=336.479 g/mol}}		1 hour (slow)\|metabolism=Hepatic (CYP3A4)\|duration=30-60 minutes\|adverse_effects=\|mechanism=μ-opioid agonism\|molar_mass=336.479 g/mol}}

	'''Fentanyl''' is an opioid used for analgesia.		'''Fentanyl''' is an opioid used for analgesia.

Chris.Rishel at 17:12, 18 February 2021

2021-02-18T17:12:50Z

← Older revision		Revision as of 10:12, 18 February 2021
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	==References==		==References==

	[[Category:Drug reference]]		[[Category:Drug reference]]
	[[Category:Opioids]]		[[Category:Opioids]]

Chris.Rishel at 17:12, 18 February 2021

2021-02-18T17:12:26Z

← Older revision		Revision as of 10:12, 18 February 2021
Line 35:		Line 35:

	==References==		==References==
			[[Category:Drug reference]]
			[[Category:Opioids]]
			[[Category:Opioid agonists]]
			[[Category:Synthetic opioids]]
			[[Category:Analgesics]]
			[[Category:Local anesthetic adjuvants]]

Chris.Rishel at 10:05, 17 February 2021

2021-02-17T10:05:46Z

← Older revision		Revision as of 03:05, 17 February 2021
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	1 hour (slow)\|metabolism=Hepatic (CYP3A4)\|duration=30-60 minutes\|adverse_effects=\|mechanism=Opioid-receptor agonism\|molar_mass=336.479 g/mol}}		1 hour (slow)\|metabolism=Hepatic (CYP3A4)\|duration=30-60 minutes\|adverse_effects=\|mechanism=Opioid-receptor agonism\|molar_mass=336.479 g/mol}}

	~~Provide a brief summary of this drug here~~.		'''Fentanyl''' is an opioid used for analgesia.

	==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==		==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==

Chris.Rishel: Created page with "{{Infobox drug reference | trade_names =Actiq, Duragesic, Sublimaze | drug_class =Opioid | drug_class_color =opioid | uses =Analgesia | contraindications = | routes =Bucc..."

2021-02-17T10:04:46Z

Created page with "{{Infobox drug reference | trade_names =Actiq, Duragesic, Sublimaze | drug_class =Opioid | drug_class_color =opioid | uses =Analgesia | contraindications = | routes =Bucc..."

New page

{{Infobox drug reference
| trade_names =Actiq, Duragesic, Sublimaze
| drug_class =Opioid
| drug_class_color =opioid
| uses =Analgesia
| contraindications =
| routes =Buccal, Epidural, Intrathecal, Intravenous, Transdermal
| dosage =
|halflife_elimination=16 hours|formula=5 minutes|image_file=Fentanyl.svg|protein_binding=80-85%|clearance=|time_onset=5 minutes|halflife_redistribution=6 minutes (initial)
1 hour (slow)|metabolism=Hepatic (CYP3A4)|duration=30-60 minutes|adverse_effects=|mechanism=Opioid-receptor agonism|molar_mass=336.479 g/mol}}

Provide a brief summary of this drug here.

==Uses==

==Contraindications==

===Absolute contraindications===

===Precautions===

==Pharmacology==

===Pharmacodynamics===

====Mechanism of action====

====Adverse effects====

===Pharmacokinetics===

==Chemistry and formulation==

==History==

==References==