Sugammadex - Revision history

Chris.Rishel: Added embedded dosage calculation

2022-03-30T07:34:53Z

Added embedded dosage calculation

← Older revision		Revision as of 00:34, 30 March 2022
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	{{Infobox drug reference		{{Infobox drug reference
	\| trade_names =Bridion		\| trade_names = Bridion
	\| drug_class =		\| drug_class =
	\| drug_class_color =neuromuscular_blocker_reversal		\| drug_class_color = neuromuscular_blocker_reversal
	\| uses =Reversal of neuromuscular blockade from [[Rocuronium\|rocuronium]] and [[Vecuronium\|vecuronium]]		\| uses = Reversal of neuromuscular blockade from [[Rocuronium\|rocuronium]] and [[Vecuronium\|vecuronium]]
	\| contraindications =Renal impairment		\| contraindications = Renal impairment
	\| routes =Intravenous		\| routes = Intravenous
	\| dosage =~~Based upon response to train-of-four stimulation:~~		\| dosage =
	* 2+ twitches: 2 mg/kg		\| halflife_elimination =
	* 1-2 posttetanic twitches: 4 mg/kg		\| formula = C<sub>72</sub>H<sub>112</sub>O<sub>48</sub>S<sub>8</sub>
	~~Reversal immediately after administration of rocuronium 1.2 mg/kg: 16 mg/kg~~		\| image_file = Sugammadex.svg
	\|halflife_elimination=\|formula=C<sub>72</sub>H<sub>112</sub>O<sub>48</sub>S<sub>8</sub>\|image_file=Sugammadex.svg\|protein_binding=\|clearance=\|time_onset=\|halflife_redistribution=\|metabolism=\|duration=\|adverse_effects=Bradycardia, may interfere with hormonal contraceptives\|mechanism=Encapsulation of rocuronium or vecuronium\|molar_mass=2002.12 g/mol}}		\| protein_binding =
			\| clearance =
			\| time_onset =
			\| halflife_redistribution =
			\| metabolism =
			\| duration =
			\| adverse_effects = Bradycardia, may interfere with hormonal contraceptives
			\| dosage_calculation = sugammadex
			\| mechanism = Encapsulation of rocuronium or vecuronium
			\| molar_mass = 2002.12 g/mol
			}}
	'''Sugammadex''' is used to reverse neuromuscular blockade from [[rocuronium]] and [[vecuronium]].		'''Sugammadex''' is used to reverse neuromuscular blockade from [[rocuronium]] and [[vecuronium]].

TymKajstura: updated contraindication section

2021-08-26T16:20:44Z

updated contraindication section

← Older revision		Revision as of 09:20, 26 August 2021
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	===Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. -->===		===Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. -->===

			* Previous anaphylactic reaction to sugammadex

	===Precautions<!-- List precautions for use of the drug. If none, this section may be removed. -->===		===Precautions<!-- List precautions for use of the drug. If none, this section may be removed. -->===

			* Sugammadex can also bind steroid-structured molecules such as estrogen and tamoxifen. Consideration to using other agents to reverse NMB should be given to those patients on tamoxifen or toremifene for breast cancer. Female patients of child-bearing age on oral birth control should be advised of the potential of a short-term decrease in the efficacy of this method of birth control following reversal with sugammadex.
			* Renal disease is a relative contraindication to the use of sugammadex as it is mainly renally cleared. With decreased renal clearance, the drug will stay in the body longer and the safety profile of this kind of drug exposure has not been well studied.

	==Pharmacology==		==Pharmacology==

Chris.Rishel at 15:00, 21 February 2021

2021-02-21T15:00:28Z

← Older revision		Revision as of 08:00, 21 February 2021
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	Reversal immediately after administration of rocuronium 1.2 mg/kg: 16 mg/kg		Reversal immediately after administration of rocuronium 1.2 mg/kg: 16 mg/kg
	\|halflife_elimination=\|formula=C<sub>72</sub>H<sub>112</sub>O<sub>48</sub>S<sub>8</sub>\|image_file=Sugammadex.svg\|protein_binding=\|clearance=\|time_onset=\|halflife_redistribution=\|metabolism=\|duration=\|adverse_effects=Bradycardia, may interfere with hormonal contraceptives\|mechanism=Encapsulation of rocuronium or vecuronium\|molar_mass=2002.12 g/mol}}		\|halflife_elimination=\|formula=C<sub>72</sub>H<sub>112</sub>O<sub>48</sub>S<sub>8</sub>\|image_file=Sugammadex.svg\|protein_binding=\|clearance=\|time_onset=\|halflife_redistribution=\|metabolism=\|duration=\|adverse_effects=Bradycardia, may interfere with hormonal contraceptives\|mechanism=Encapsulation of rocuronium or vecuronium\|molar_mass=2002.12 g/mol}}

	'''Sugammadex''' is used to reverse neuromuscular blockade from [[rocuronium]] and [[vecuronium]].		'''Sugammadex''' is used to reverse neuromuscular blockade from [[rocuronium]] and [[vecuronium]].

Chris.Rishel at 14:40, 21 February 2021

2021-02-21T14:40:16Z

← Older revision		Revision as of 07:40, 21 February 2021
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	\| routes =Intravenous		\| routes =Intravenous
	\| dosage =Based upon response to train-of-four stimulation:		\| dosage =Based upon response to train-of-four stimulation:

	* 2+ twitches: 2 mg/kg		* 2+ twitches: 2 mg/kg
	* 1-2 posttetanic twitches: 4 mg/kg		* 1-2 posttetanic twitches: 4 mg/kg
	~~<br/>~~
	Reversal immediately after administration of rocuronium 1.2 mg/kg: 16 mg/kg		Reversal immediately after administration of rocuronium 1.2 mg/kg: 16 mg/kg
	\|halflife_elimination=\|formula=C<sub>72</sub>H<sub>112</sub>O<sub>48</sub>S<sub>8</sub>\|image_file=Sugammadex.svg\|protein_binding=\|clearance=\|time_onset=\|halflife_redistribution=\|metabolism=\|duration=\|adverse_effects=Bradycardia, may interfere with hormonal contraceptives\|mechanism=Encapsulation of rocuronium or vecuronium\|molar_mass=2002.12 g/mol}}		\|halflife_elimination=\|formula=C<sub>72</sub>H<sub>112</sub>O<sub>48</sub>S<sub>8</sub>\|image_file=Sugammadex.svg\|protein_binding=\|clearance=\|time_onset=\|halflife_redistribution=\|metabolism=\|duration=\|adverse_effects=Bradycardia, may interfere with hormonal contraceptives\|mechanism=Encapsulation of rocuronium or vecuronium\|molar_mass=2002.12 g/mol}}

Chris.Rishel at 17:16, 18 February 2021

2021-02-18T17:16:08Z

← Older revision		Revision as of 10:16, 18 February 2021
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	==References==		==References==
	<references />		<references />
			[[Category:Drug reference]]
			[[Category:Antidotes]]
			[[Category:Neuromuscular blocker reversal agents]]

Chris.Rishel at 13:11, 18 February 2021

2021-02-18T13:11:28Z

@@ Line 17: / Line 17: @@
 ==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==
 ==Contraindications<!-- List contraindications and precautions for use of the drug. -->==
@@ Line 39: / Line 52: @@
 ==References==

Chris.Rishel: Created page with "{{Infobox drug reference | trade_names =Bridion | drug_class = | drug_class_color =neuromuscular_blocker_reversal | uses =Reversal of neuromuscular blockade from Rocuroni..."

2021-02-18T13:02:20Z

Created page with "{{Infobox drug reference | trade_names =Bridion | drug_class = | drug_class_color =neuromuscular_blocker_reversal | uses =Reversal of neuromuscular blockade from Rocuroni..."

New page

{{Infobox drug reference
| trade_names =Bridion
| drug_class =
| drug_class_color =neuromuscular_blocker_reversal
| uses =Reversal of neuromuscular blockade from [[Rocuronium|rocuronium]] and [[Vecuronium|vecuronium]]
| contraindications =Renal impairment
| routes =Intravenous
| dosage =Based upon response to train-of-four stimulation:

* 2+ twitches: 2 mg/kg
* 1-2 posttetanic twitches: 4 mg/kg
 
Reversal immediately after administration of rocuronium 1.2 mg/kg: 16 mg/kg
|halflife_elimination=|formula=C72H112O48S8|image_file=Sugammadex.svg|protein_binding=|clearance=|time_onset=|halflife_redistribution=|metabolism=|duration=|adverse_effects=Bradycardia, may interfere with hormonal contraceptives|mechanism=Encapsulation of rocuronium or vecuronium|molar_mass=2002.12 g/mol}}

'''Sugammadex''' is used to reverse neuromuscular blockade from [[rocuronium]] and [[vecuronium]].

==Uses==

==Contraindications==

===Absolute contraindications===

===Precautions===

==Pharmacology==

===Pharmacodynamics===

====Mechanism of action====

====Adverse effects====

===Pharmacokinetics===

==Chemistry and formulation==

==History==

==References==